Studies of the dynamic changes in the ovarian follicular basal lamina

卵巢滤泡基底层动态变化的研究

• 批准号: nhmrc : 102130
• 负责人: Prof Raymond Rodgers
• 金额: $ 20.37万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2000
• 资助国家: 澳大利亚
• 起止时间: 2000-01-01 至 2002-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/studies-dynamic-changes-basal-lamina/95401
• 关键词: Studies; dynamic; changes; ovarian; follicular

In order for the ovary to be able to release eggs and produce hormones such as oestrogen, follicles must grow within the ovary. Each follicle contains one egg and when the follicle is large and filled with fluid it can rupture, releasing the fluid and egg in the process of ovulation. A key part of the structure of the follicle is a non-cellular layer called the basal lamina. This basal lamina encapsulates the inner cells, the egg and the fluid in the follicle. Each women has millions of follicles prior to her birth, ten of thousands in her reproductive years, and none at the menopause. Since she only ovulates about 500 in her lifetime most follicles die during the process of growing to ovulatory size. This project will examine the follicular basal lamina in order to determine its role during follicle growth and development, and when follicles die. This has important implications for the many women who have polycystic ovarian disease, whose follicles fail to grow to full size. We will be examining these ovaries directly. The research also has importance in the next phase of IVF developments.

为了使卵巢能够释放卵子并产生雌激素等激素，卵泡必须在卵巢内生长。每个卵泡包含一个卵子，当卵泡很大并充满液体时，它会破裂，在排卵过程中释放液体和卵子。卵泡结构的一个关键部分是一个非细胞层，称为基底层。基底膜包裹着卵泡内的内细胞、卵子和卵泡液。每个女性在出生前都有数百万个卵泡，在生育年龄有数万个卵泡，而在更年期没有卵泡。由于她一生中只排卵约500个，大多数卵泡在生长到排卵大小的过程中死亡。本计画将检视卵泡基底层，以确定其在卵泡生长发育及死亡时所扮演的角色。这对许多患有多囊卵巢疾病的女性具有重要意义，她们的卵泡无法生长到完整的大小。我们将直接检查这些卵巢。这项研究对IVF发展的下一阶段也很重要。