Studies of the Role of the Hepatocyte in the Response to HCV Infection

肝细胞在 HCV 感染反应中的作用研究

• 批准号: nhmrc : 1051585
• 负责人: Prof Alexander Thompson
• 金额: $ 34.23万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/studies-role-hepatocyte-hcv-infection/112226
• 关键词: Studies; Role; Hepatocyte; Response; HCV

Infection with hepatitis C (HCV) affects 120 million individuals worldwide, and over 200,000 in Australia. HCV-related liver disease is the most common indication for liver transplantation in Australia and rates of HCV-related liver failure and hepatocellular cancer are predicted to increase as the HCV population ages. A new test for the IL28B gene, has shown to be the strongest predictor of cure after treatment. The mechanism of this association is unknown and is the subject of this grant.

丙型肝炎 (HCV) 感染影响全球 1.2 亿人，澳大利亚超过 20 万人。 HCV 相关肝病是澳大利亚肝移植最常见的适应症，预计 HCV 相关肝衰竭和肝细胞癌的发生率会随着 HCV 人群老龄化而增加。 IL28B 基因的一项新测试已被证明是治疗后治愈的最强预测因子。该关联的机制尚不清楚，并且是本次拨款的主题。