A whole genome association study for determinants of clinical outcome and treatment response in chronic hepatitis C

慢性丙型肝炎临床结果和治疗反应决定因素的全基因组关联研究

• 批准号: nhmrc : 567057
• 负责人: Prof Alexander Thompson
• 金额: $ 24.01万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/genome-association-study-hepatitis-c/116038
• 关键词: whole; genome; association; study; determinants

Chronic hepatitis C infection (CHC) causes liver failure, liver cancer and death. The treatment response rate is poor. Understanding of the factors that increase an individual’s risk of developing serious liver disease, or that lead to treatment failure, is limited. This project, the first of its kind, will involve screening 1600 CHC patients for genes that are associated with disease outcome and treatment response, to identify novel targets for drug and vaccine development

慢性丙型肝炎感染（CHC）会导致肝功能衰竭、肝癌和死亡。治疗有效率较差。对于增加个体发展为严重肝脏疾病风险或导致治疗失败的因素的了解是有限的。这是首个此类项目，将对1600名CHC患者进行筛查，寻找与疾病结局和治疗反应相关的基因，以确定药物和疫苗开发的新靶点