Studies on the role of the MIP-3beta/SLC system in the priming phase of the cytotoxic T lymphocyte response.

研究 MIP-3beta/SLC 系统在细胞毒性 T 淋巴细胞反应启动阶段的作用。

• 批准号: nhmrc : 250359
• 负责人: Prof Shaun Mccoll
• 金额: $ 28.36万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2003
• 资助国家: 澳大利亚
• 起止时间: 2003-01-01 至 2005-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/studies-role-mip-lymphocyte-response/78195
• 关键词: Studies; role; MIP; 3beta; SLC

Generation of cytotoxic T cells (CTLs) is important for defence against viruses and cancer cells. However, when activated inappropriately, CTLs can contribute to diseases such as diabetes as well as transplant rejection. We intend to study the role of several recently-discovered proteins in this process. The outcome of this work may lead to the development of molecules that control CTL generation more specifically than existing therapeutics. Such inhibitors would potentially be useful in the treatment of a range of human diseases.

细胞毒性 T 细胞 (CTL) 的生成对于防御病毒和癌细胞非常重要。然而，如果激活不当，CTL 可能会导致糖尿病和移植排斥等疾病。我们打算研究几种最近发现的蛋白质在此过程中的作用。这项工作的结果可能会导致比现有疗法更具体地控制 CTL 生成的分子的开发。此类抑制剂可能可用于治疗一系列人类疾病。