Upregulation of chemokine receptor expression and function on CD4+ T cells in primary and secondary immune responses

初级和次级免疫反应中 CD4 T 细胞趋化因子受体表达和功能的上调

• 批准号: nhmrc : 349533
• 负责人: Prof Shaun Mccoll
• 金额: $ 31.31万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2005
• 资助国家: 澳大利亚
• 起止时间: 2005-01-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/upregulation-chemokine-receptor-immune-responses/95827
• 关键词: Upregulation; chemokine; receptor; expression; function

This research will begin to determine the significance of changes in the amount of recently-discovered proteins on the surface of cells called T lymphocytes. These cells control immune responses and move throughout the body to do this. Sometimes, they are activated inappropriately and cause diseases like asthma, arthritis and multiple sclerosis and other times they need assistance for activation (vaccination). It is therfore important to understand how the movement of these cells through the body is controlled. A better understanding of this process shuld allow us to design better ways to control it, thereby controlling the negative aspects of T lymphocyte activation.

这项研究将开始确定最近发现的T淋巴细胞表面蛋白质数量变化的意义。这些细胞控制免疫反应，并在整个身体中移动。有时，它们被不适当地激活并导致哮喘，关节炎和多发性硬化症等疾病，其他时候它们需要激活（疫苗接种）的帮助。因此，了解这些细胞在体内的运动是如何被控制的是很重要的。更好地理解这一过程将使我们能够设计更好的方法来控制它，从而控制T淋巴细胞活化的负面影响。