Understanding the mechanism and significance of CXCL16-mediated protection of tumour cells from CTL-induced apoptosis.

了解 CXCL16 介导的保护肿瘤细胞免受 CTL 诱导的细胞凋亡的机制和意义。

• 批准号: nhmrc : 399160
• 负责人: Prof Shaun Mccoll
• 金额: $ 34.98万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2006
• 资助国家: 澳大利亚
• 起止时间: 2006-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-mechanism-significance-induced-apoptosis/101320
• 关键词: Understanding; mechanism; significance; CXCL16; mediated

This research will begin to determine the significance of changes in the amount of a recently-discovered protein on the surface of tumour cells. We have shown that an increase in expression of this protein protects tumour cells from destruction by our immune system's killer T cells. The outcome of this research could lead to a better understanding of how the immune system recognises and kills tumour cells, and ultimately, alternate vaccine strategies for tumours.

这项研究将开始确定肿瘤细胞表面最近发现的蛋白质数量变化的意义。我们已经证明，这种蛋白质表达的增加可以保护肿瘤细胞免受免疫系统杀伤T细胞的破坏。这项研究的结果可以更好地了解免疫系统如何识别和杀死肿瘤细胞，并最终为肿瘤提供替代疫苗策略。