Study of motor inhibition deficits in schizophrenia using MRI, EventRelatedPotentialsand Transcranial Magnetic stimulation

使用 MRI、事件相关电位和经颅磁刺激研究精神分裂症的运动抑制缺陷

• 批准号: nhmrc : 386501
• 负责人: A/Pr Patrick Johnston
• 金额: $ 17.45万
• 依托单位: Swinburne University of Technology
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2006
• 资助国家: 澳大利亚
• 起止时间: 2006-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/study-motor-inhibition-magnetic-stimulation/114584
• 关键词: Study; motor; inhibition; deficits; schizophrenia

The aim of the proposed project is to study the neural mechanism underlying failures of motor-inhibition in patients with schizophrenia. The project will involve the use of fMRI and ERP measures during performance of a Stop-Signal Task, in order to explore the neural substrates of task performance in healthy subjects, and activational differences in schizophrenia patients. In a separate experimental session TMS will be applied in order to disrupt neural processing at cortical sites identified by fMRI. Systematic use of TMS across different cortical sites will be used to compare effects of cortical site and subject group on task performance.

该项目的目的是研究精神分裂症患者运动抑制失败的神经机制。该项目将涉及在执行停止信号任务期间使用功能磁共振成像和 ERP 测量，以探索健康受试者任务执行的神经基础以及精神分裂症患者的激活差异。在一个单独的实验中，将应用 TMS 来破坏功能磁共振成像识别的皮质部位的神经处理。在不同皮质部位系统地使用 TMS 将用于比较皮质部位和受试者组对任务表现的影响。