Studying the function and mechanism of histone ADP-ribosylation; (ii) Lipo-peptide--protein vaccine development

研究组蛋白ADP-核糖基化的功能和机制；

• 批准号: nhmrc : 569869
• 负责人: Dr Peter Moyle
• 金额: $ 33.08万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/studying-function-mechanism-vaccine-development/116137
• 关键词: Studying; function; mechanism; histone; ADP

(i) Histones, which act as DNA supports, are subject to modifications, which may be associated with disease (e.g. cancers). A better understanding of these modifications will provide access to new medicines (ii) The production of new vaccines requires new vaccine development tools. We propose to use fats to produce vaccines which can be delivered via the mouth or nose rather than by injection.

(i)作为DNA载体的组蛋白会发生修饰，这可能与疾病（例如癌症）有关。更好地了解这些修改将提供获得新的药物（二）新疫苗的生产需要新的疫苗开发工具。我们建议使用脂肪来生产疫苗，这些疫苗可以通过口或鼻而不是注射来输送。