Developing a multicomponent platform for targeted gene delivery

开发用于靶向基因传递的多组件平台

• 批准号: DP200101271
• 负责人: Dr Peter Moyle
• 金额: $ 36.08万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2020
• 资助国家: 澳大利亚
• 起止时间: 2020-06-19 至 2024-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP200101271
• 关键词: Developing; multicomponent; platform; targeted; gene

Gene delivery systems are important tools in biological research and offer many exciting future prospects. Delivering gene material is very difficult in practice: rapid deterioration, poor cell uptake, and reaching the right tissue and cell types are major obstacles. Ways to overcome each barrier individually have been suggested in existing research but these components have not yet been combined in a single solution, which this project will tackle. This proposal aims to create a technology to stabilise and deliver active gene material to target cells. The gene delivery tool developed in this project will advance biological research greatly with many potential future applications.

基因传递系统是生物学研究的重要工具，具有许多令人兴奋的前景。传递基因材料在实践中非常困难：快速退化、细胞摄取不良以及到达正确的组织和细胞类型是主要障碍。在现有的研究中已经提出了单独克服每个障碍的方法，但是这些组件还没有结合在一个单一的解决方案中，这个项目将解决这个问题。这项提议旨在创造一种技术来稳定并将活性基因物质输送到靶细胞。该项目开发的基因传递工具将极大地推进生物学研究，具有许多潜在的未来应用前景。