Sun exposure, vitamin D and the outcome of prostate cancer.

阳光照射、维生素 D 和前列腺癌的结果。

• 批准号: nhmrc : 464850
• 负责人: A/Pr David Smith
• 金额: $ 32.99万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/sun-exposure-vitamin-prostate-cancer/99729
• 关键词: Sun; exposure; vitamin; outcome; prostate

We will find out whether hours of sun exposure, reported in a standard interview by men with prostate cancer, reduces prostate cancer recurrence and progression. For any effect of sun exposure ithat we observe, we will find out whether it works through vitamin D, which is produced by sunshine on the skin, or is affected by changes in the vitamin D receptor gene, which produces the protein the binds with vitamin D on cells and makes it work. Prostate cancer is the most common cancer in men in Australia, and this study, using two of the largest collections of clinical outcomes data for this disease, will inform researchers, clinicians and consumers about the possible benefits of sun exposure and Vitamin D in the prevention of recurrence or progression of prostate cancer. On present evidence, these effects are very plausible possibilities. It may also identify sub-groups of men in whom sun exposure or vitamin D might be particularly beneficial in improving outcome of prostate cancer.

我们将发现在前列腺癌患者的标准访谈中报告的数小时的阳光照射是否会减少前列腺癌的复发和进展。对于我们观察到的任何阳光照射的影响，我们将发现它是否通过维生素D起作用，维生素D是由阳光照射在皮肤上产生的，还是受到维生素D受体基因变化的影响，该基因产生蛋白质，与细胞上的维生素D结合并使其发挥作用。前列腺癌是澳大利亚男性中最常见的癌症，这项研究使用了这种疾病的两个最大的临床结果数据集，将告知研究人员，临床医生和消费者阳光照射和维生素D在预防前列腺癌复发或进展方面的可能益处。根据目前的证据，这些影响是非常合理的可能性。它还可以确定男性的亚组，其中阳光照射或维生素D可能对改善前列腺癌的结果特别有益。