Five year outcomes of care for prostate cancer in New South Wales

新南威尔士州前列腺癌护理的五年结果

• 批准号: nhmrc : 387700
• 负责人: A/Pr David Smith
• 金额: $ 25.92万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2006
• 资助国家: 澳大利亚
• 起止时间: 2006-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/year-outcomes-care-south-wales/94465
• 关键词: Five; year; outcomes; care; prostate

Prostate cancer is the most common cancer in Australian males after non-melanocytic skin cancer. Each year more than 10,000 men are diagnosed with prostate cancer, and over 2,500 die from it. While the issue of early detection of prostate cancer through the use of Prostate Specific Antigen test continues to raise debate, the longer term quality of life outcomes after treatment for this disease remain of great interest to patients, clinicians and health planners. The Prostate Cancer Outcomes Study is an already established research project that was established in 2000 with the aim of documenting the quality of life outcomes of 2000 men with prostate cancer to five years after diagnosis. The Department of Veterans Affairs funded the study between 2000 and 2005, to establish the cohort, collect patterns of care information from clinicians and quality of life information from participants to 3 years post diagnosis. We are now seeking funds to complete the quality of life follow up for each surviving participant at five years after diagnosis. We also will assess rate of recurrence of prostate cancer to five years and seek support to be able to undertake linkage with death certificate information to determine the vital status of each study subject and begin analysis of five-year survival rates. Five-year quality of life information will be the main endpoint for this part of the study. Initial analysis of the three-year data showed a continued improvement in outcomes related to urinary and sexual function. We wish to determine whether these improvements continue to five years and the extent of the difference, at that time, between men with prostate cancer and men without prostate cancer (controls), whom we are also studying. This information will be uniquely useful in helping men make decisions about treatment options when diagnosed with prostate cancer.

前列腺癌是澳大利亚男性中继非黑素细胞皮肤癌之后最常见的癌症。每年有超过 10,000 名男性被诊断患有前列腺癌，超过 2,500 人死于前列腺癌。虽然通过使用前列腺特异性抗原测试早期检测前列腺癌的问题仍然引起争论，但患者、临床医生和健康规划者仍然对这种疾病治疗后的长期生活质量结果非常感兴趣。前列腺癌结果研究是一项已确定的研究项目，成立于 2000 年，旨在记录 2000 名前列腺癌男性诊断后五年内的生活质量结果。退伍军人事务部在 2000 年至 2005 年间资助了这项研究，以建立队列，收集临床医生的护理模式信息以及参与者诊断后 3 年内的生活质量信息。我们现在正在寻求资金，以便在诊断后五年内完成每位幸存参与者的生活质量随访。我们还将评估前列腺癌五年内的复发率，并寻求支持，以便能够与死亡证明信息建立联系，以确定每个研究对象的生命状况，并开始分析五年生存率。五年生活质量信息将是这部分研究的主要终点。对三年数据的初步分析显示，与泌尿和性功能相关的结果持续改善。我们希望确定这些改善是否会持续五年，以及当时我们也在研究的患有前列腺癌的男性和未患前列腺癌的男性（对照）之间的差异程度。这些信息对于帮助男性在诊断出患有前列腺癌时做出治疗选择的决定非常有用。