Suppression of immunity by the malaria parasite antigen Plasmodium falciparum Erythrocyte Membrane Protein-1 (PfEMP-1)

疟疾寄生虫抗原恶性疟原虫红细胞膜蛋白 1 (PfEMP-1) 对免疫的抑制

• 批准号: nhmrc : 1038030
• 负责人: Dr Natalia Sampaio
• 金额: $ 6.45万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Postgraduate Scholarships
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/suppression-immunity-malaria-pfemp-1/111113
• 关键词: Suppression; immunity; malaria; parasite; antigen

The malaria parasite P. falciparum infects red blood cells and makes the cells put on their surface a protein called PfEMP-1. The parasite can effectively “hide” by constantly changing this protein and making it unrecognizable by the immune system. PfEMP-1 can also suppress the immune system so that it can’t respond adequately to infection. Therefore, understanding PfEMP-1 function is important. I will investigate how PfEMP-1 can do this by looking at its cross talk with the immune system.

恶性疟原虫感染红细胞，使红细胞表面产生一种名为PfEMP-1的蛋白质。寄生虫可以通过不断改变这种蛋白质并使其无法被免疫系统识别来有效地“隐藏”。PfEMP-1还可以抑制免疫系统，使其无法对感染做出充分反应。因此，了解PfEMP-1的功能非常重要。我将研究PfEMP-1如何通过观察它与免疫系统的相互作用来做到这一点。