T-follicular helper cell subsets that induce protective anti-Plasmodium falciparum antibodies

疟疾每年至少夺去50万人的生命，其中大多数是5岁以下的儿童。为了开发有效的疟疾疫苗，至关重要的是，我们增加我们对自然暴露人群中诱导保护性免疫反应的关键机制的理解。这个项目将研究一个重要的细胞亚群-T-滤泡辅助细胞-在抗疟疾免疫力发展中的作用。

Malaria claims at least half a million lives each year, the majority of them in children under the age of 5 years. In order to development effective vaccines malaria it is critically important that we increase our understanding of the key mechanisms governing the induction of protective immune responses in naturally exposed populations. This project will examine the role of one important cell subset - T-follicular helper cells - in the development of immunity against malaria.