T-follicular helper cell subsets that induce protective anti-Plasmodium falciparum antibodies

诱导保护性抗恶性疟原虫抗体的滤泡辅助 T 细胞亚群

• 批准号: nhmrc : 1125656
• 负责人: Dr Michelle Boyle
• 金额: $ 31.18万
• 依托单位: Macfarlane Burnet Institute for Medical Research and Public Health
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/t-follicular-helper-falciparum-antibodies/947644
• 关键词: follicular; helper; cell; subsets; induce

Malaria claims at least half a million lives each year, the majority of them in children under the age of 5 years. In order to development effective vaccines malaria it is critically important that we increase our understanding of the key mechanisms governing the induction of protective immune responses in naturally exposed populations. This project will examine the role of one important cell subset - T-follicular helper cells - in the development of immunity against malaria.

疟疾每年夺去至少 50 万人的生命，其中大多数是 5 岁以下的儿童。为了开发有效的疟疾疫苗，至关重要的是我们加深对自然暴露人群中诱导保护性免疫反应的关键机制的了解。该项目将研究一种重要的细胞亚群——滤泡辅助T细胞——在疟疾免疫力发展中的作用。