T-follicular helper cell subtypes that induce protective anti-malaria antibodies

疟疾在全球造成重大疾病负担。目前还没有适合广泛使用的疟疾疫苗。由于对人类免疫系统如何对抗疟疾的了解有限，有效疫苗的开发受到阻碍。该项目将使用收集的人类样本来研究人类血细胞如何激活免疫系统来对抗疟疾。这项研究将确定未来改进疟疾疫苗设计的途径。

Malaria causes significant disease burden globally. Currently there are no malarial vaccines that are suitable for widespread use. The development of effective vaccines is hampered by limited understanding of how the human immune system fights malaria. This project will use human samples collected to investigate how human blood cells activate the immune system to fight malaria. This research will identify avenues to improve the design of malaria vaccines in the future.