Identifying T cell correlates of protective immunity to malaria in childhood

识别儿童期疟疾保护性免疫的 T 细胞相关性

• 批准号: nhmrc : 1071736
• 负责人: Dr Michelle Boyle
• 金额: $ 26.41万
• 依托单位: Macfarlane Burnet Institute for Medical Research and Public Health
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/identifying-t-cell-malaria-childhood/455472
• 关键词: Identifying; cell; correlates; protective; immunity

Malaria claims nearly one million lives each year, mostly children. Although those living in endemic regions can acquire natural immunity, it develops slowly and isn`t completely protective. This project studies the impact of different levels of malaria exposure and age on the development of a protective immune response in children. By understanding the effect of high malaria exposure in the development of immunity it is hoped that new avenues for drug development may be identified.

疟疾每年夺去近100万人的生命，其中大多数是儿童。虽然那些生活在流行地区的人可以获得天然免疫力，但它发展缓慢，不能完全保护。该项目研究不同程度的疟疾暴露和年龄对儿童保护性免疫反应的影响。通过了解高疟疾暴露对免疫力发展的影响，人们希望可以确定药物开发的新途径。