Tapping the power of pluripotency: The role of HMGA1 in stem cell self-renewal and cell fate transitions

发挥多能性的力量：HMGA1 在干细胞自我更新和细胞命运转变中的作用

• 批准号: nhmrc : GNT1138870
• 负责人: A/Pr Chen Davidovich
• 金额: $ 52.03万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/tapping-power-pluripotency-fate-transitions/1348188
• 关键词: Tapping; power; pluripotency; role; HMGA1

Stem-cell-based therapies have great potential as new treatments for degenerative and genetic diseases. However, to ensure we move in the right direction, we need a detailed understanding of stem cell properties. We have recently identified a novel mechanism for controlling stem-cell-like properties in both normal and cancer stem cells. In this project, we will further investigate this new means of controlling stem cells, which could revolutionise future therapeutic strategies for many diseases.

基于干细胞的疗法作为退化性和遗传疾病的新疗法具有很大的潜力。但是，为了确保我们朝着正确的方向移动，我们需要详细了解干细胞特性。我们最近确定了一种在正常和癌症干细胞中控制干细胞样性质的新型机制。在这个项目中，我们将进一步研究这种控制干细胞的新方法，这可能会彻底改变许多疾病的未来治疗策略。