Targeted nanoparticles to deliver combinations of calcium channel inhibitors to prevent myelin damage during secondary degeneration after neurotrauma

靶向纳米颗粒可递送钙通道抑制剂组合，以防止神经外伤后继发性变性过程中髓磷脂损伤

• 批准号: nhmrc : 1082403
• 负责人: A/Pr Killugudi Swaminatha-Iyer
• 金额: $ 59.69万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/targeted-nanoparticles-deliver-degeneration-neurotrauma/518876
• 关键词: Targeted; nanoparticles; deliver; combinations; calcium

Following injury to the central nervous system the damage spreads into nearby areas, leading to worse outcomes for the patient. We will generate nanoparticle systems to deliver effective therapies directly to the most vulnerable cells, critical for function. We will modify the nanoparticles so that they can get to the injury site, both early after injury, and after longer periods of time have elapsed. We will then test the nanoparticle systems to see if they are effective at preserving function

在中枢神经系统损伤后，损伤会扩散到附近区域，导致患者的预后更差。我们将生产纳米颗粒系统，直接向最脆弱的细胞提供有效的治疗，这对功能至关重要。我们将修改纳米颗粒，使它们能够到达受伤部位，无论是在受伤后的早期，还是在经过较长时间后。然后，我们将测试纳米颗粒系统，看看它们是否能有效地保持功能