Targeting early cellular damage during secondary degeneration using nanosphere-based drug delivery

使用基于纳米球的药物输送靶向继发性变性期间的早期细胞损伤

• 批准号: nhmrc : 1028681
• 负责人: A/Pr Killugudi Swaminatha-Iyer
• 金额: $ 28.3万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/targeting-early-cellular-drug-delivery/110658
• 关键词: Targeting; early; cellular; damage; during

After brain injury, there are no treatments to stop the spread of damage to intact tissue, a process involving different cell types and biochemical events. Clinical trials have targeted one event and have failed because large therapeutic doses are toxic and because combined treatments are needed to target different events. We will harness nanotechnology to target delivery of small, sustained doses of one or more drugs to specific cell types and biochemical events to stop the spread of damage.

脑损伤后，没有任何治疗方法可以阻止损伤对完整组织的扩散，这一过程涉及不同的细胞类型和生化事件。临床试验针对的是一种事件，但失败了，因为大剂量的治疗剂量是有毒的，而且需要针对不同的事件进行联合治疗。我们将利用纳米技术将一种或多种小剂量、持续剂量的药物定向输送到特定的细胞类型和生化事件，以阻止损害的蔓延。