Targeting a bacterial glyco-Achilles heel to make new vaccines for Haemophilus influenzae and Neisseria gonorrhoeae.

针对细菌糖基阿基里斯之踵来制造流感嗜血杆菌和淋病奈瑟菌的新疫苗。

• 批准号: nhmrc : 2001210
• 金额: $ 52.7万
• 依托单位国家: 澳大利亚
• 项目类别: Ideas Grants
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/targeting-bacterial-glyco-neisseria-gonorrhoeae/1779729
• 关键词: Targeting; bacterial; glyco; Achilles; heel

The bacteria that cause gonorrhoea (N. gonorrhoeae), middle ear infections and exacerbations of chronic obstructive lung disease (H. influenzae) have become multi-drug resistant. These diseases are a major health and economic burden. In the absence of new drugs, a vaccine to prevent these diseases has emerged as a major unmet need in human health. In this grant, we will develop a new vaccine that targets a bacterial-specific sugar that we have discovered is the Achilles heel of these bacteria.

导致淋病的细菌（N.淋病）、中耳感染和慢性阻塞性肺病（H.流感）已经变得具有多药耐药性。这些疾病是一个重大的健康和经济负担。在没有新药的情况下，预防这些疾病的疫苗已成为人类健康中一个未得到满足的主要需求。在这项资助中，我们将开发一种新的疫苗，该疫苗针对一种细菌特异性糖，我们发现这种糖是这些细菌的致命弱点。