Targeting Bcl-2 pathways in parasites

靶向寄生虫中的 Bcl-2 通路

• 批准号: nhmrc : 1002227
• 负责人: A/Pr Bernd Kalinna
• 金额: $ 32.45万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/targeting-bcl-2-pathways-parasites/108788
• 关键词: Targeting; Bcl; pathways; parasites

Schistosomiasis is one of the world's most serious and prevalent diseases affecting nearly 200 million people world-wide. It is currently treated with a single drug, though there is growing concern about the development of resistance to it. In this proposal we will explore whether a new cellular pathway involving the cell death machinery we have identified in the disease-causing parasites could provide a possible target for the development of new treatments against schistosomiasis.

血吸虫病是世界上最严重和流行的疾病之一，影响着全世界近2亿人。目前，它是用一种单一的药物治疗，虽然有越来越多的关注的耐药性的发展it.In这个提案中，我们将探讨是否一个新的细胞通路，涉及我们已经确定的细胞死亡机制的致病寄生虫可以提供一个可能的目标，发展新的治疗血吸虫病。