Somatic gene trapping in Schistosoma mansoni _ the key to functional analysis

曼氏血吸虫体细胞基因捕获_功能分析的关键

• 批准号: nhmrc : 1004230
• 负责人: A/Pr Bernd Kalinna
• 金额: $ 41.56万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/somatic-gene-trapping-functional-analysis/109017
• 关键词: Somatic; gene; trapping; Schistosoma; mansoni

Blood flukes are endemic in 76 countries and infect 300 million people worldwide. Control largely relies on the drug praziquantel. However, its wide scale use has led to concerns that drug resistance will develop. In this study we will use ñgene trap vectorsî to introduce insertional mutations into the schistosome genome. This will help to understand the function and importance of genes in biochemical pathways used by the parasite and to define effective targets for drug and vaccine development.

血吸虫在76个国家流行，全世界有3亿人感染。控制主要依靠药物吡喹酮。然而，它的广泛使用导致了人们对耐药性的担忧。在这项研究中，我们将使用基因陷阱载体将插入突变引入到染色体基因组中。这将有助于了解寄生虫使用的生化途径中基因的功能和重要性，并确定药物和疫苗开发的有效靶点。