Targeting bone marrow mediated angiogenesis and metastasis in breast cancer

靶向乳腺癌中骨髓介导的血管生成和转移

• 批准号: nhmrc : 1011114
• 负责人: A/Pr Albert Mellick
• 金额: $ 30.87万
• 依托单位: University of Western Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/targeting-bone-marrow-breast-cancer/109549
• 关键词: Targeting; bone; marrow; mediated; angiogenesis

Despite advances in treatment and diagnostics breast cancer (BC) remains one of the leading causes of death in women. Metastases and tumour blood vessel recruitment are linked. Work by Dr Mellick and others has shown that host bone marrow contributes endothelial progenitor cells (EPCs) to tumour vasculature. The chemokines and their receptors, which differentiate EPCs from tumour vessels, will be knocked down in the tumour cells and EPC progenitors with the aim of preventing tumour spread.

尽管在治疗和诊断方面取得了进展，但乳腺癌仍然是妇女死亡的主要原因之一。转移和肿瘤血管募集是相关的。Mellick博士和其他人的工作表明，宿主骨髓为肿瘤血管系统提供内皮祖细胞（EPCs）。将EPC与肿瘤血管区分开的趋化因子及其受体将在肿瘤细胞和EPC祖细胞中被敲低，目的是防止肿瘤扩散。