Targeting Tumour Angiogenesis in Breast Cancer by Altering MicroRNA Signalling

通过改变 MicroRNA 信号传导靶向乳腺癌中的肿瘤血管生成

• 批准号: nhmrc : 1047522
• 负责人: A/Pr Albert Mellick
• 金额: $ 44.02万
• 依托单位: University of Western Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/targeting-tumour-angiogenesis-microrna-signalling/111946
• 关键词: Targeting; Tumour; Angiogenesis; Breast; Cancer

Despite advances in treatment, breast cancer remains one of the leading underlying causes of death and disability in Australia. Preventing cancer spread therefore has the potential for enormous economic and social outcomes. Small RNAs have recently been identified as key regulators of cancer cell biology. This project seeks to take a leadership role in the area of small RNA biology by targeting small RNAs implicated in blood vessel formation as a means of suppressing breast cancer spread.

尽管在治疗方面取得了进展，但乳腺癌仍然是澳大利亚死亡和残疾的主要潜在原因之一。因此，预防癌症扩散有可能产生巨大的经济和社会成果。小RNA最近被鉴定为癌细胞生物学的关键调节因子。该项目旨在通过靶向与血管形成有关的小RNA作为抑制乳腺癌扩散的手段，在小RNA生物学领域发挥领导作用。