Targeting the canonical Wnt signalling pathway to promote central nervous system remyelination in vivo

靶向经典Wnt信号通路促进体内中枢神经系统髓鞘再生

• 批准号: nhmrc : GNT1111041
• 负责人: Dr David Gonsalvez
• 金额: $ 31.46万
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/targeting-canonical-wnt-remyelination-vivo/1346758
• 关键词: Targeting; canonical; Wnt; signalling; pathway

Multiple Sclerosis (MS) occurs when immune cells attack the sheaths, called myelin, that cover and protect nerve connections. If myelin is damaged nerve cells cannot function properly, leading to severe disability. The brain has a group of cells that could potentially replace damaged myelin, but as MS worsens these cells are blocked in a state where they cannot help in repair. I will remove a signal specifically from these cells and determine if this unblocks them resulting myelin repair.

多发性硬化症（MS）发生时，免疫细胞攻击鞘，称为髓鞘，覆盖和保护神经连接。如果髓磷脂受损，神经细胞就不能正常工作，导致严重残疾。大脑中有一组细胞可以潜在地取代受损的髓鞘，但是随着MS的发展，这些细胞被阻止在一种无法帮助修复的状态下。我将从这些细胞中移除一个特定的信号，并确定这是否会导致髓鞘修复。