Targeting CD40L(CD154) on dendritic cells for CD8 T cell-mediated immunity and tolerance

靶向树突状细胞上的 CD40L（CD154）以实现 CD8 T 细胞介导的免疫和耐受

• 批准号: nhmrc : 637324
• 负责人: Dr Yifan Zhan
• 金额: $ 37.24万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/targeting-cd40lcd154-dendritic-immunity-tolerance/98964
• 关键词: Targeting; CD40L; CD154; dendritic; cells

Killer T cells fight infection but also participate in transplant rejection. Activation of killer T cells often requires helper T cells. However, in the absence of helper cells, we have found an alternative pathway by which killer cells can be activated. We will explore this new pathway in enhancing vaccine responses and in modulating transoplant rejection.

杀伤T细胞对抗感染，但也参与移植排斥反应。杀伤T细胞的激活通常需要辅助T细胞。然而，在没有辅助细胞的情况下，我们发现了另一种激活杀伤细胞的途径。我们将探索这一新的途径，以增强疫苗反应和调节移植排斥反应。