Functional suicide of selected dendritic cells by cytochrome c: an in vivo model lacking cross-presentation

细胞色素 c 导致选定树突状细胞的功能性自杀：缺乏交叉呈递的体内模型

• 批准号: nhmrc : 575543
• 负责人: Dr Yifan Zhan
• 金额: $ 39.84万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/functional-suicide-selected-cross-presentation/98440
• 关键词: Functional; suicide; selected; dendritic; cells

Certain white blood cells (dendritic cells) activate the immune system, especially its T cells. Infection of such cells elicits killer T cell responses. However not all infections infect dendritic cells. In such cases, the infectious material is eaten by dendritic cells and moved to certain areas within the cell. This process is called cross-presentation and how important it is during various diseases remains moot. We now have a model of testing this by eliminating these cross-presenting cells.

某些白色血细胞（树突细胞）激活免疫系统，特别是其T细胞。这些细胞的感染激发了杀伤T细胞应答。然而，并非所有感染都会感染树突状细胞。在这种情况下，感染性物质被树突细胞吃掉并移动到细胞内的某些区域。这个过程被称为交叉呈现，它在各种疾病中的重要性仍然没有定论。我们现在有了一个通过消除这些交叉呈递细胞来测试这一点的模型。