Targeting Cell Death Pathways in Malignant Mesothelioma

靶向恶性间皮瘤的细胞死亡途径

• 批准号: nhmrc : GNT1157551
• 金额: $ 46.31万
• 依托单位: La Trobe University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/targeting-cell-death-malignant-mesothelioma/1378992
• 关键词: Targeting; Cell; Death; Pathways; Malignant

Malignant mesothelioma (MM) is an aggressive and incurable cancer with median patient survival of 12 months. By screening a panel of MM cell lines against a new class of drugs that directly target the natural cell death mechanisms in tumour cells, we identified two specific 'survival factors' in MM. Co-targeting of these molecules leads to potent MM cell killing. The proposed research will expand these studies into animal model of MM and potentially provide new treatment options for MM patients.

恶性间皮瘤(MM)是一种侵袭性和不可治愈的癌症，患者的中位生存期为12个月。通过筛选一组MM细胞株来对抗一类直接针对肿瘤细胞中自然细胞死亡机制的新药物，我们确定了MM中的两个特定的“生存因素”。共同靶向这些分子会导致强大的MM细胞杀伤。这项研究将把这些研究扩展到多发性骨髓瘤的动物模型，并有可能为多发性骨髓瘤患者提供新的治疗选择。