Targeting Cell Death Pathways in Malignant Mesothelioma

恶性间皮瘤（MM）是一种侵袭性和不可治愈的癌症，患者的中位生存期为12个月。通过筛选一组MM细胞系对抗一类直接靶向肿瘤细胞中自然细胞死亡机制的新型药物，我们在MM中确定了两种特定的“生存因子”。这些分子的共同靶向导致有效的MM细胞杀伤。拟议的研究将把这些研究扩展到MM的动物模型中，并可能为MM患者提供新的治疗选择。

Malignant mesothelioma (MM) is an aggressive and incurable cancer with median patient survival of 12 months. By screening a panel of MM cell lines against a new class of drugs that directly target the natural cell death mechanisms in tumour cells, we identified two specific 'survival factors' in MM. Co-targeting of these molecules leads to potent MM cell killing. The proposed research will expand these studies into animal model of MM and potentially provide new treatment options for MM patients.