Targeting inflammatory skin disease using an immune-modulatory human signal peptide

使用免疫调节人类信号肽治疗炎症性皮肤病

• 批准号: nhmrc : 2002727
• 金额: $ 69.88万
• 依托单位国家: 澳大利亚
• 项目类别: Ideas Grants
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/targeting-inflammatory-skin-signal-peptide/1779978
• 关键词: Targeting; inflammatory; skin; disease; using

Effective drugs are desperately needed for the improved treatment of inflammatory diseases. We will determine how a modified human peptide, which we have discovered and can make, works to suppress harmful skin inflammation. We will design new formulations to deliver our drug to the skin in order to better treat psoriasis, an autoinflammatory skin disease. We will also trial our new drug in models of atopic dermatitis a debilitating skin disease for which there is limited treatment options.

迫切需要有效的药物来改善炎症性疾病的治疗。我们将确定我们已经发现并可以制造的修饰的人类肽如何抑制有害的皮肤炎症。我们将设计新的配方，将我们的药物输送到皮肤，以更好地治疗牛皮癣，一种自身炎症性皮肤病。我们还将在特应性皮炎模型中试验我们的新药，特应性皮炎是一种使人衰弱的皮肤病，治疗选择有限。