Targeting KCa3.1 in diabetic nephropathy

靶向 KCa3.1 治疗糖尿病肾病

• 批准号: nhmrc : 1025918
• 负责人: A/Pr Xin-Ming Chen
• 金额: $ 40.1万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/targeting-kca31-diabetic-nephropathy/110459
• 关键词: Targeting; KCa3.1; diabetic; nephropathy

Renal failure is a major cause of morbidity and mortality in persons with diabetes mellitus and accounts for the majority of renal disease worldwide. Renal fibrosis is the end result of progressive kidney disease. The proposed research aims to identify a new strategy by targeting specific channels in kidney cell membranes to arrest the development of enal fibrosis and hence progressive kidney disease caused by diabetes mellitus.

肾衰竭是糖尿病患者发病和死亡的主要原因，占全球肾脏疾病的大多数。肾纤维化是进行性肾病的最终结果。这项研究旨在通过靶向肾细胞膜中的特定通道来确定一种新的策略，以阻止肾纤维化的发展，从而阻止糖尿病引起的进行性肾脏疾病。