TGFbeta isoforms differentially regulate fibrosis and inflammation in diabetic nephropathy via KLF transcription factors

TGFbeta亚型通过KLF转录因子差异调节糖尿病肾病的纤维化和炎症

• 批准号: nhmrc : 512170
• 负责人: A/Pr Xin-Ming Chen
• 金额: $ 36.05万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/tgfbeta-isoforms-differentially-transcription-factors/77686
• 关键词: TGFbeta; isoforms; differentially; regulate; fibrosis

Progressive scarring and inflammation in the kidney represent the final common injury pathway for diseases that lead to kidney failure, including diabetic nephropathy. This project explores the interplay between the molecular processes that are triggered by high glucose levels in patients with diabetic nephropathy, some of which are deleterious and some potentially 'protective'. By understanding these mechanisms we will be able to prevent and more effectively treat kidney disease in diabetes.

肾脏的进行性瘢痕和炎症是导致肾衰竭的疾病的最终常见损伤途径，包括糖尿病肾病。该项目探讨了糖尿病肾病患者中由高葡萄糖水平引发的分子过程之间的相互作用，其中一些是有害的，一些是潜在的“保护”。通过了解这些机制，我们将能够预防和更有效地治疗糖尿病肾病。