Targeting Post-translational Modifications in TRPV Pain Channels

结合辣椒刺激性成分(TRPV1)的同一神经受体是我们疼痛通路的重要组成部分。TRPV1也会对疼痛的高温和酸产生反应。慢性疼痛是一种重要的未得到满足的医疗需求，它使用TRPV1途径。在被辣椒激活后，神经中的反馈系统会使TRPV1失活，并停止疼痛信号。这种反馈会在慢性疼痛中发生变化。本项目旨在了解和利用这种反馈机制，以找到疼痛治疗的新方法。

The same nerve receptor that binds the pungent component of chilli peppers (TRPV1) is an important part of our pain pathway. TRPV1 also responds to painful heat and acids. Chronic pain is an important unmet medical need and it uses the TRPV1 pathway. After activation by chilli, a feedback system in nerves inactivates TRPV1 and stops pain signalling. This feedback changes in chronic pain. This project aims to understand and exploit this feedback mechanism to find new approaches to pain therapy.