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Spectroscopy and biosensors for turbid media

Spectroscopy and biosensors for turbid media
浑浊介质的光谱学和生物传感器
批准号：
155504-2008
负责人：
Burns, David
金额：
$3.21万
依托单位：
McGill University
依托单位国家：
加拿大
项目类别：
Discovery Grants Program - Individual
财政年份：
2009
资助国家：
加拿大
项目状态：
已结题
起止时间：
2009-01-01 至 2010-12-31
来源：
https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=422566
关键词：
Spectroscopybiosensorsturbidmedia

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英文摘要
The goal of this work is to develop quantitative, depth-resolved measurements in scattering media for both high and low concentration consituents. Variable scattering limits quantification of analytes in cell suspensions and tissue measurements. For high concentration components we propose to combine optical patterned illumination with near-infrared spectroscopy and chemometrics, to provide depth-resolved quantification. We will extend the sensitivity of detection for low concentration analytes using dispersed ultrasonically active micro-sensors, which change optical and ultrasonic properties upon analyte binding. The specific objectives to be undertaken are divided into two parallel efforts:
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