Androgen-induced neuroplasticity in the hippocampus and cerebral cortex

雄激素诱导的海马和大脑皮层神经可塑性

• 批准号: 197293-2007
• 负责人: MacLusky, Neil
• 金额: $ 2.08万
• 依托单位: University of Guelph
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2009
• 资助国家: 加拿大
• 起止时间: 2009-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=423354
• 关键词: Androgen; induced; neuroplasticity; hippocampus; cerebral

Androgens enhance cognitive function, contributing to the normal sex differences in cognitive behavior observed in many vertebrates. How these effects occur remains unknown. We have demonstrated that administration of androgens to castrated rats markedly increases the density of synapses on the apical dendritic spines of neurons in the hippocampus and the prefrontal cortex (PFC). Since increased spine synapse density in these areas of the brain is associated with learning and memory, we hypothesize that this effect may represent part of the mechanism for the positive effects of the steroids on cognitive function.

雄激素增强认知功能，导致在许多脊椎动物中观察到的认知行为的正常性别差异。这些影响是如何发生的仍然未知。 我们已经证明，雄性激素给去势大鼠的海马和前额叶皮层（PFC）的神经元的顶端树突棘上的突触密度显着增加。由于大脑这些区域的棘突触密度增加与学习和记忆有关，我们假设这种作用可能代表类固醇对认知功能的积极作用机制的一部分。