Th17 cell Cytokines in Airway Wall Remodelling in Chronic Asthma.

在哮喘中，气道壁发生结构变化，使肌肉和上皮层增厚，使气道变硬并增加粘液的产生。这种“重塑”使呼吸更加困难，目前的治疗方法无法有效逆转。我们将研究参与这些变化发展的细胞和分子。这个项目将增加我们对驱动这些变化的过程的理解，并可能导致改进药物的发展。

In asthma, structural changes in the airway wall occur which thicken the muscle and epithelial layers, stiffen the airways and increase mucus production. This 'remodelling' makes breathing more difficult and is not effectively reversed with current treatments. We will study the cells and molecules involved in the development of these changes. This project will increase our understanding of the processes which drive these changes and may lead to the development of improved medications.