Th17 cell Cytokines in Airway Wall Remodelling in Chronic Asthma.

慢性哮喘气道壁重塑中的 Th17 细胞细胞因子。

• 批准号: nhmrc : 568812
• 负责人: Dr Cristan Herbert
• 金额: $ 19.74万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/th17-cell-cytokines-chronic-asthma/95227
• 关键词: Th17; cell; Cytokines; Airway; Wall

In asthma, structural changes in the airway wall occur which thicken the muscle and epithelial layers, stiffen the airways and increase mucus production. This 'remodelling' makes breathing more difficult and is not effectively reversed with current treatments. We will study the cells and molecules involved in the development of these changes. This project will increase our understanding of the processes which drive these changes and may lead to the development of improved medications.

在哮喘中，气道壁发生结构变化，使肌肉和上皮层增厚，气道变硬并增加粘液产生。这种“重塑”使呼吸变得更加困难，并且当前的治疗方法无法有效逆转。我们将研究参与这些变化发展的细胞和分子。该项目将增加我们对推动这些变化的过程的理解，并可能导致改进药物的开发。