Chemotactic Cytokines Gordon Research Conference and Seminar

项目总结： 趋化因子系统由趋化因子、它们的同源G蛋白偶联受体和它们的 非典型受体，在结构上相关，但不与G蛋白偶联。这是一种不同寻常的 有颌骨脊椎动物几乎所有的生理过程都涉及到多样性和混杂的网络。 这种复杂性要求从不同的角度和不同的工具来研究系统， 方法和技术。趋化因子系统的一个显著特征是引导细胞迁移和 将单元格定位在特定的位置。2022年戈登趋化研究会议(GRC) 细胞因子：“在健康和疾病中协调细胞迁移和定位”是一项国际研究 著名的会议致力于解开机制和揭示新的功能 趋化因子系统。这将是第14届Chemokine GRC，每隔一届举行一次 自1994年(除2020年外)，趋化因子首次成为最大的细胞因子基因家族 在人类基因组中。和过去一样，趋化细胞因子GRC 2022将吸引来自 不同的生物医学学科，讨论最新的未发表的结果，这些结果将解决许多方面的问题 趋化因子相关研究。拟议的计划呼吁优秀的专家，他们将提出新的 调查结果、新概念和潜在影响，包括翻译角度。因此， 会议将讨论与其作用有关的趋化因子的基本生化和生物学方面。 细胞迁移、免疫功能及其在炎症、感染、自身免疫和癌症中的作用。 会议还将讨论潜在药物和疾病治疗策略的新发展。GRC 将像最近的四个版本一样，伴随着卫星戈登研究研讨会(GRS) 趋化性细胞因子。GRS《探索趋化因子系统：从结构到功能》是 专为年轻科学家、研究生和早期博士后设计。这些下一代 科学家将展示他们的工作，并从他们的同行和 来自选定的高级国际知名领域专家小组，同时论坛 将促进趋化因子研究领域内的整合和联网。美国国立卫生研究院申请拨款 为参与者的注册提供部分支持。我们充分预计，科学的 讨论、研究演讲、海报会议以及参与者之间的非正式互动 会议将有助于增进我们对趋化因子分子机制的理解 参与健康和疾病。会议将促进新的合作伙伴关系的发展 项目，这将导致新的发现，并最终产生新的治疗方法和方法 使人衰弱的病理，包括炎症、自身免疫、传染病和癌症。

PROJECT SUMMARY: The chemokine system consists of chemokines, their cognate G-protein coupled receptors and their atypical receptors, which are structurally related but do not couple to G-proteins. It is an unusually diverse and promiscuous network involved in almost every physiological process of jawed vertebrates. The complexity requires studying the system from different viewpoints and with different tools, approaches and techniques. A prominent feature of the chemokine system is to guide cell migration and position cells in specific niches. The 2022 Gordon Research Conference (GRC) on Chemotactic Cytokines: "Orchestrating cell migration and localization in health and disease" is an internationally renowned meeting dedicated to deconvolute the mechanisms and unveil new functions of the chemokine system. This will be the 14th edition of the Chemokine GRC, which has been held every other year since 1994 (except for 2020), when chemokines first emerged as the largest cytokine gene family in the human genome. As in the past, the Chemotactic Cytokine GRC 2022 will attract scientists from diverse biomedical disciplines to discuss the latest unpublished results that will tackle many aspects of chemokine-related research. The proposed program calls on outstanding specialist that will present new findings, new concepts and potential implications, including translational perspectives. Hence, the meeting will cover basic biochemical and biological aspects of chemokines related to their contributions to cell migration, immune function, and their role in inflammation, infection, autoimmunity and cancer. New developments in potential drugs and disease treatment strategies will also be discussed. The GRC will, like at the recent four editions, be accompanied by a satellite Gordon Research Seminar (GRS) on Chemotactic Cytokines. The GRS "Exploring the chemokine system: from structures to functions" is particularly designed for young scientists, graduate students and early postdocs. These next generation scientists will present their work and receive feedback on their research projects from their peers and from a selected panel of senior internationally renowned field experts and at the same time the forum will promote integration and networking within the field of chemokine research. NIH funding is requested to provide partial support for registration of the participants. We fully anticipate that the scientific discussions, research talks, poster sessions, and informal interactions between the participants of this conference will contribute to advancing our understanding of molecular mechanisms of chemokine involvement in health and disease. The conference will foster the development of new collaborative projects, which will lead to new discoveries and ultimately new therapies and approaches to treat debilitating human pathologies, including inflammatory, autoimmune, infectious diseases and cancer.