Chemotactic Cytokines Gordon Research Conference and Seminar

项目概要： 趋化因子系统由趋化因子、它们的同源G蛋白偶联受体和它们的 非典型受体，其在结构上相关但不与G蛋白偶联。这是一个不寻常的 在几乎所有的有颌脊椎动物的生理过程中参与的多样化和混杂的网络。 复杂性要求从不同的角度和不同的工具来研究系统， 方法和技术。趋化因子系统的一个突出特征是引导细胞迁移， 将细胞定位在特定的小生境中。2022年戈登研究会议（GRC）的趋化性 细胞因子：“在健康和疾病中促进细胞迁移和定位”是国际上 著名的会议，致力于解开机制和揭示新的职能， 趋化因子系统这将是第14版的趋化因子GRC，这已经举行了每隔 自1994年以来的一年（2020年除外），趋化因子首次成为最大的细胞因子基因家族 在人类基因组中。与过去一样，趋化性细胞因子GRC 2022将吸引来自 不同的生物医学学科，讨论最新的未发表的结果，将解决许多方面的问题， 趋化因子相关研究。拟议的计划呼吁杰出的专家，将提出新的 研究结果、新概念和潜在影响，包括翻译观点。所以 会议将涵盖趋化因子的基本生物化学和生物学方面， 细胞迁移、免疫功能及其在炎症、感染、自身免疫和癌症中的作用。 还将讨论潜在药物和疾病治疗策略的新发展。集团风险管理委员会 将，像在最近的四个版本，伴随着一个卫星戈登研究研讨会（GRS）上 趋化性细胞因子。GRS“探索趋化因子系统：从结构到功能”是 特别为年轻科学家、研究生和早期博士后设计。这些下一代 科学家们将展示他们的工作，并从同行那里获得对他们研究项目的反馈， 由国际知名的资深专家组成的专家小组，同时， 将促进趋化因子研究领域的整合和网络化。申请NIH资助 为参与者的注册提供部分支持。我们完全预计， 讨论，研究会谈，海报会议，以及参与者之间的非正式互动， 会议将有助于推进我们对趋化因子分子机制的理解 参与健康和疾病。会议将促进新的合作发展， 项目，这将导致新的发现，并最终新的疗法和方法来治疗 使人衰弱的病理学，包括炎性、自身免疫性、感染性疾病和癌症。

PROJECT SUMMARY: The chemokine system consists of chemokines, their cognate G-protein coupled receptors and their atypical receptors, which are structurally related but do not couple to G-proteins. It is an unusually diverse and promiscuous network involved in almost every physiological process of jawed vertebrates. The complexity requires studying the system from different viewpoints and with different tools, approaches and techniques. A prominent feature of the chemokine system is to guide cell migration and position cells in specific niches. The 2022 Gordon Research Conference (GRC) on Chemotactic Cytokines: "Orchestrating cell migration and localization in health and disease" is an internationally renowned meeting dedicated to deconvolute the mechanisms and unveil new functions of the chemokine system. This will be the 14th edition of the Chemokine GRC, which has been held every other year since 1994 (except for 2020), when chemokines first emerged as the largest cytokine gene family in the human genome. As in the past, the Chemotactic Cytokine GRC 2022 will attract scientists from diverse biomedical disciplines to discuss the latest unpublished results that will tackle many aspects of chemokine-related research. The proposed program calls on outstanding specialist that will present new findings, new concepts and potential implications, including translational perspectives. Hence, the meeting will cover basic biochemical and biological aspects of chemokines related to their contributions to cell migration, immune function, and their role in inflammation, infection, autoimmunity and cancer. New developments in potential drugs and disease treatment strategies will also be discussed. The GRC will, like at the recent four editions, be accompanied by a satellite Gordon Research Seminar (GRS) on Chemotactic Cytokines. The GRS "Exploring the chemokine system: from structures to functions" is particularly designed for young scientists, graduate students and early postdocs. These next generation scientists will present their work and receive feedback on their research projects from their peers and from a selected panel of senior internationally renowned field experts and at the same time the forum will promote integration and networking within the field of chemokine research. NIH funding is requested to provide partial support for registration of the participants. We fully anticipate that the scientific discussions, research talks, poster sessions, and informal interactions between the participants of this conference will contribute to advancing our understanding of molecular mechanisms of chemokine involvement in health and disease. The conference will foster the development of new collaborative projects, which will lead to new discoveries and ultimately new therapies and approaches to treat debilitating human pathologies, including inflammatory, autoimmune, infectious diseases and cancer.