Airway epithelial injury and the innate lymphoid cell response in the pathogenesis of allergic asthma

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Exposure to airborne particulate pollutants appears to contribute both to the development of childhood asthma and to acute severe attacks of asthma. We will investigate the mechanisms involved, using mouse models of childhood asthma and of asthma exacerbations. In particular, we will focus on the potentially critical role of a newly described population of host defence cells, and how these are activated as a result of injury of the lining cells of the airways.