Airway epithelial injury and the innate lymphoid cell response in the pathogenesis of allergic asthma

过敏性哮喘发病机制中的气道上皮损伤和先天淋巴细胞反应

• 批准号: nhmrc : 1060660
• 负责人: Dr Cristan Herbert
• 金额: $ 40.51万
• 依托单位: The University of Newcastle
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/airway-epithelial-injury-allergic-asthma/454842
• 关键词: Airway; epithelial; injury; innate; lymphoid

Exposure to airborne particulate pollutants appears to contribute both to the development of childhood asthma and to acute severe attacks of asthma. We will investigate the mechanisms involved, using mouse models of childhood asthma and of asthma exacerbations. In particular, we will focus on the potentially critical role of a newly described population of host defence cells, and how these are activated as a result of injury of the lining cells of the airways.

暴露于空气中的颗粒污染物似乎有助于儿童哮喘的发展和哮喘的急性严重发作。我们将使用儿童哮喘和哮喘急性发作的小鼠模型来研究所涉及的机制。特别是，我们将集中在一个新描述的宿主防御细胞群体的潜在关键作用，以及这些是如何被激活的结果，损伤的衬里细胞的气道。