The collagen-rich matrix as a driver of breast cancer progression and resistance to therapy

富含胶原蛋白的基质是乳腺癌进展和治疗耐药的驱动因素

• 批准号: nhmrc : 2000937
• 金额: $ 70.22万
• 依托单位国家: 澳大利亚
• 项目类别: Ideas Grants
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/the-collagen-rich-resistance-therapy/1779672
• 关键词: collagen; rich; matrix; driver; breast

The extracellular matrix or 'matrix' surrounds all cells and is very important in controlling cell behaviour. In cancer, the matrix is dramatically altered, making cancer more aggressive. We recently developed a new way to study the matrix in breast cancer, and have analysed the matrix at different stages (Early/Mid/Late). We have uncovered exciting new matrix targets associated with more aggressive tumours. This project will validate their potential as therapeutic targets in breast cancer.

细胞外基质或“基质”包围所有细胞，并且在控制细胞行为方面非常重要。在癌症中，基质发生了显着变化，使癌症更具侵略性。我们最近开发了一种新的方法来研究乳腺癌中的基质，并分析了不同阶段（早期/中期/晚期）的基质。我们已经发现了与更具侵袭性的肿瘤相关的令人兴奋的新基质靶点。该项目将验证它们作为乳腺癌治疗靶点的潜力。