The Effect of Statin and Colchicine on Pericoronary Adipose Tissue Inflammation and Coronary Artery Plaque Progression: Insights from Cardiac Computed Tomography Using Pericoronary Adipose Tissue Attenuation and Radiomics

他汀类药物和秋水仙碱对冠状动脉周围脂肪组织炎症和冠状动脉斑块进展的影响：使用冠状动脉周围脂肪组织衰减和放射组学的心脏计算机断层扫描的见解

• 批准号: nhmrc : 2002573
• 金额: $ 12.54万
• 依托单位国家: 澳大利亚
• 项目类别: Postgraduate Scholarships
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/the-effect-statin-attenuation-radiomics/1780431
• 关键词: Effect; Statin; Colchicine; Pericoronary; Adipose

Coronary artery disease is the leading cause of death in Australia. Inflammation is a key driver of harmful build-up of cholesterol plaques in arteries. Currently it is unclear how to detect patients with high level of inflammation. We examine a new approach to detect coronary inflammation using CT coronary angiography (CTCA). We investigate how to utilise CTCA to guide targeted therapy with statin and colchicine in patients with residual inflammation to reduce risk of future heart attack.

冠状动脉疾病是澳大利亚的主要死亡原因。炎症是动脉中有害胆固醇斑块积聚的关键驱动因素。目前尚不清楚如何检测高水平炎症的患者。我们研究了一种新的方法来检测冠状动脉炎症使用CT冠状动脉造影（CTCA）。我们研究了如何利用CTCA指导他汀类药物和秋水仙碱在残留炎症患者中的靶向治疗，以降低未来心脏病发作的风险。