Novel accoustical and optical methods to probe the structure of biomaterials

Kolios博士实验室的工作重点是使用新颖的光和超声技术来表征生物材料的结构和组成。他和他的团队特别感兴趣的是应用这些技术来监测癌症治疗过程中细胞和组织的变化。他的工作包括使用高频超声波监测细胞死亡和使用光声监测热疗法治疗。在这项提案中，一种基于光的技术，称为光学相干断层扫描，将以光谱的方式用于推断治疗过程中细胞结构的变化，并与目前正在进行的高频超声工作进行比较。此外，一种基于超声的技术，声传输成像，将用于观察在超声治疗期间发生的组织变化，其中使用高强度超声消除病理组织。高强度超声波可以将组织加热到60 ℃以上，或者足够短以引起机械组织破裂而不产生显著的热量。我们将研究声学摄像机的效用，以监测这些治疗的组织特性的变化。这项工作将最终导致更好地了解这些技术在临床应用中的优势和局限性。

The work in Dr. Kolios' laboratory focuses on using novel light and ultrasound technologies to characterize the structure and composition of biomaterials. Of particular interest to him and his group is the application of these technologies to monitor the changes in cells and tissues during cancer therapies. Examples of his work include the use of high frequency ultrasound to monitor cell death and the use of photoacoustics to monitor thermal therapy treatments. In this proposal, one light-based technology, called optical coherence tomography, will be used in a spectroscopic manner to infer changes in the structure of cells during treatment, and compared to the high frequency ultrasound work that is currently underway. Moreover, one ultrasound based technology, acoustic transmission imaging, will be used to look at changes in tissue that occur during ultrasound therapies, in which pathological tissues are eliminated using high intensity ultrasound. The high intensity ultrasound can either heat the tissues to over 60C, or be short enough to causing mechanical tissue disruption without the production of significant heat. We will investigate the utility of the acoustic camera to monitor changes in tissue properties from these treatments. This work will ultimately lead to a better understanding of the strengths and limitations with regards to the clinical use of these technologies.