Therapeutic relevance of AT2 receptors in cardiovascular disease and aging

AT2 受体在心血管疾病和衰老中的治疗相关性

• 批准号: nhmrc : 384237
• 负责人: Prof Harald Schmidt
• 金额: $ 34.63万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2006
• 资助国家: 澳大利亚
• 起止时间: 2006-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/therapeutic-relevance-at2-disease-aging/81658
• 关键词: Therapeutic; relevance; AT2; receptors; cardiovascular

Pharmacological modulation of the renin angiotensin system is a cornerstone of evidence-based cardiovascular therapeutics. However, their molecular mechanisms are not entirely clear and some therapeutic options have not been utilized to their full potential. The hormone angiotensin II causes both excitatory and inhibitory cardiovascular effects via distinct binding sites. Of particular importance to contemporary society is the shift in the demographic to a more aged population. In Australia in 2002, 13% of the population (~2.5 million) were aged 65 years or over, and it has been estimated that this number will increase to 18% (~4 million) by the year 2021. While lipid status and smoking are well known risk factors for cardiovascular disease, advanced age by far confers the greatest risk for cardiovascular disease. In this context, we have found a greater role of the inhibitory angiotensin II binding site in aging that may result from breakdown products of angiotensin II having their own unique effects. This project will determine the relative role of various angiotensin products, and novel compounds that may act similarly, to improve vascular tone and reverse cardiovascular disease in the elderly, hypertensive population.

肾素血管紧张素系统的药理学调节是循证心血管治疗的基石。然而，它们的分子机制尚不完全清楚，一些治疗方案尚未充分发挥其潜力。血管紧张素 II 激素通过不同的结合位点引起兴奋性和抑制性心血管效应。对当代社会特别重要的是人口结构向老龄化的转变。 2002 年，澳大利亚有 13% 的人口（约 250 万）年龄在 65 岁或以上，预计到 2021 年这一数字将增加到 18%（约 400 万）。虽然血脂状况和吸烟是众所周知的心血管疾病的危险因素，但迄今为止，高龄是心血管疾病的最大风险。在这种情况下，我们发现抑制性血管紧张素 II 结合位点在衰老中发挥更大的作用，这可能是由于血管紧张素 II 的分解产物具有其独特的作用。该项目将确定各种血管紧张素产品以及可能具有类似作用的新型化合物的相对作用，以改善老年高血压人群的血管张力并逆转心血管疾病。