A redox sensor and triple receptor function for guanylyl cyclase

鸟苷酸环化酶的氧化还原传感器和三重受体功能

• 批准号: DP0667150
• 负责人: Prof Harald Schmidt
• 金额: $ 20.62万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2006
• 资助国家: 澳大利亚
• 起止时间: 2006-01-03 至 2008-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0667150
• 关键词: redox; sensor; triple; receptor; function

Nitric oxide (NO) protects from blood vessel spasms and clot formation. Conversely, insufficient NO occurs in cardiovascular disease. Life-saving drugs like glycerol trinitrate supply more NO to blood vessels, however these drugs are limited in their action when their target protein (NOGC) is decreased or defective, eg. in hypertension or arteriosclerosis. We have elucidated the reason for this defect and simultaneously discovered an entirely novel group of drugs which activate NOGC without NO. Impressively, these drugs are most effective in diseased blood vessels. The aim is the development of novel blood pressure lowering/anti-anginal drugs with higher effectiveness and less side-effects because they work in an entirely new way.

一氧化氮 (NO) 可防止血管痉挛和血栓形成。相反，NO 不足会导致心血管疾病。像三硝酸甘油这样的救生药物可以向血管提供更多的 NO，但是当它们的靶蛋白 (NOGC) 减少或有缺陷时，这些药物的作用就会受到限制。高血压或动脉硬化。我们已经阐明了这种缺陷的原因，同时发现了一组全新的药物，可以在没有 NO 的情况下激活 NOGC。令人印象深刻的是，这些药物对病变血管最有效。其目的是开发新型降压/抗心绞痛药物，因为它们以全新的方式发挥作用，因此具有更高的有效性和更少的副作用。