A redox sensor and triple receptor function for guanylyl cyclase

一氧化氮(NO)可防止血管痉挛和血栓形成。相反，在心血管疾病中，一氧化氮不足。像三硝酸甘油这样的救命药物为血管提供了更多的NO，然而当它们的靶蛋白(NOGC)减少或缺陷时，这些药物的作用就会受到限制。高血压或动脉硬化症。我们已经阐明了这一缺陷的原因，同时发现了一组全新的药物，可以在没有NO的情况下激活NOGC。令人印象深刻的是，这些药物对病变的血管最有效。其目的是开发新的降压/抗心绞痛药物，因为它们以一种全新的方式发挥作用，因此具有更高的有效性和更少的副作用。

Nitric oxide (NO) protects from blood vessel spasms and clot formation. Conversely, insufficient NO occurs in cardiovascular disease. Life-saving drugs like glycerol trinitrate supply more NO to blood vessels, however these drugs are limited in their action when their target protein (NOGC) is decreased or defective, eg. in hypertension or arteriosclerosis. We have elucidated the reason for this defect and simultaneously discovered an entirely novel group of drugs which activate NOGC without NO. Impressively, these drugs are most effective in diseased blood vessels. The aim is the development of novel blood pressure lowering/anti-anginal drugs with higher effectiveness and less side-effects because they work in an entirely new way.