Tissue Engineering for the Periodontium

牙周组织工程

• 批准号: nhmrc : 102455
• 负责人: Prof Mark Bartold
• 金额: $ 15.98万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2000
• 资助国家: 澳大利亚
• 起止时间: 2000-01-01 至 2002-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/tissue-engineering-periodontium/96452
• 关键词: Tissue; Engineering; Periodontium

Periodontal disease is an inflammatory disorder leading to tooth loosening and, if untreated, tooth loss. Once bone destruction has occurred around teeth the treatment outcomes are severely compromised and are mainly focussed towards slowing the process of destruction rather than repairing the damage. Over the last decade, treatment of advanced periodontal disease has focussed on ways in which the damaged tissues may be regenerated. We now have gained considerable insight into the molecular and cellular events associated with periodontal regeneration. Despite efforts to induce regeneration through the selective use of growth and differentiation factors it is becoming obvious that the most significant factor in successful clinical outcomes is the recruitment of special cells to the site of damage which have the potential to repair tissue damage. Thus, we intend to engineer different types of periodontal matrices in the laboratory and then transplant these newly formed tissues into sites affected by periodontal disease in an attempt to repair the damage caused by the disease process.

牙周病是一种炎症性疾病，导致牙齿松动，如果不治疗，牙齿脱落。一旦牙齿周围发生骨质破坏，治疗效果就会受到严重影响，并且主要集中在减缓破坏过程而不是修复损伤。在过去的十年中，晚期牙周病的治疗集中在受损组织再生的方法上。我们现在已经对与牙周再生相关的分子和细胞事件有了相当深入的了解。尽管通过选择性使用生长和分化因子来诱导再生的努力，但越来越明显的是，成功的临床结果中最重要的因素是将具有修复组织损伤潜力的特殊细胞募集到损伤部位。因此，我们打算在实验室中设计不同类型的牙周基质，然后将这些新形成的组织移植到受牙周病影响的部位，以修复疾病过程造成的损伤。