TP53 variant classification models to improve clinical care of patients

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New gene testing methods are finding sequence changes in the multi-cancer gene TP53 in many cancer patients, but the consequences and cancer risk is uncertain for most variants. This hinders genetic counselling and appropriate clinical management of patients and their at-risk relatives. Using national and international expertise, this study aims to improve and standardise TP53 gene variant classification and communication to clinicians for better patient management and outcomes.