TRACEBACK - identification of women carrying germline BRCA1/2 mutations through a retrospective analysis of patients diagnosed with high grade serous ovarian cancer.

TRACEBACK - 通过对诊断为高级别浆液性卵巢癌的患者进行回顾性分析，识别携带种系 BRCA1/2 突变的女性。

• 批准号: nhmrc : 1133906
• 金额: $ 5.67万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Postgraduate Scholarships
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/traceback-identification-women-ovarian-cancer/948907
• 关键词: TRACEBACK; identification; women; carrying; germline

Inheriting a mutated-BRCA is associated with significant risk of developing cancer. It is a crucial diagnosis to make with proven procedures that can reduce the risk of cancer developing. Ovarian cancer (HGSOC) is the tumour most strongly associated with BRCA (15-20%) and provides a diagnostic opportunity, but despite Australian guidelines <50% receive testing. Our aim is to provide BRCA1/2 screening opportunities to patients and families and improve the rate of BRCA testing Australia wide.

遗传 BRCA 突变与罹患癌症的显着风险相关。这是通过经过验证的程序进行的重要诊断，可以降低患癌症的风险。卵巢癌 (HGSOC) 是与 BRCA (15-20%) 相关性最强的肿瘤，并提供了诊断机会，但尽管澳大利亚指南规定，<50% 的患者接受了检测。我们的目标是为患者和家庭提供 BRCA1/2 筛查机会，并提高澳大利亚范围内的 BRCA 检测率。