Cohort Administration and Biorepository Core
Cohort Administration and Biorepository Core
批准号:
10633366
负责人:
Antti Seppo
金额:
$23.99万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2023
资助国家:
美国
项目状态:
未结题
起止时间:
2023-04-07 至 2028-03-31
关键词:
6 year oldAgeAllergensAllergicAllergic DiseaseAsthmaAtopic DermatitisBiological MarkersBirthChildChildhoodClinicClinicalCohort StudiesCommunitiesConsumptionCountyDataDevelopmentDiagnosisDiseaseEpigenetic ProcessEpithelial CellsEquipment and supply inventoriesEuropeExposure toFamilyFarmFecesFingersFirst Degree RelativeFood HypersensitivityGerman populationHay feverHomeHouse DustHypersensitivityImmuneImmunologic MarkersImmunologyImpairmentIncidenceIndividualInfantInfant DevelopmentInflammatoryInnate Immune SystemInsuranceLifeLife StyleLivestockMeasuresMedicalMennoniteMetabolic PathwayMetadataMilkNorth AmericaOutcomePatient Self-ReportPermeabilityPhysiciansPopulationPregnant WomenPrevention strategyPrimary PreventionProcessProductionRegulatory T-LymphocyteResearch PersonnelRiskSamplingSchool-Age PopulationSecondary PreventionSiblingsSigns and SymptomsSkinSurveysSwabTSLP geneTestingVisitWomanatopybiobankbiomarker identificationclinical developmentcohortcomparison groupcomputerized data processingcytokinedata infrastructureearly childhoodearly onsetfollow-upfood allergengut microbiomehigh riskinfant gut microbiomemetabolomemicrobialmicrobiome compositionneonatenovel strategiesperipheral bloodprenatalprogramsrecruitresearch clinical testingrespiratorysample collectionshared databaseskin barriersymposiumunpasteurizedurban children
中文摘要
项目摘要/摘要-队列管理和生物库核心
英文摘要
PROJECT SUMMARY/ABSTRACT – COHORT ADMINISTRATION & BIOREPOSITORY CORE
A large body of data suggests that living on farms is associated with a decreased risk of asthma and atopic
diseases, including studies from Europe and the North America. The individual factors that appear to be
associated with this “farm-life effect” include consumption of unpasteurized farm milk and exposure to farm
animals and stables. Farm children have higher numbers of regulatory T cells, compared to urban children, and
their innate immune system also appears to be the target for these exposures. House dust in farm homes has
greater microbial diversity that is strongly negatively associated with the incidence of asthma. The studies thus
far have focused on outcomes of asthma at school-age. However, atopic dermatitis and food allergy commonly
precede development of respiratory allergies in a so-called “atopic march”. Our studies in the Old Order
Mennonite Community have indicated that they are at low risk for atopic diseases and the infant gut microbiome
composition is different from Rochester infants.
The Cohort Admin and Biorepository Core will form the sample and data infrastructure for the distinct but
complementary Projects 1-3 of this U19 Program, “Biomarkers of Atopy Beginning Early” (BABE). The Core
will follow up and expand an ongoing longitudinal birth cohort study of OOM neonates at a very low risk for atopic
dermatitis, food allergies, hayfever and asthma and Rochester neonates from atopic families with a high risk for
developing these atopic manifestations. We will test the overall hypothesis that infant gut microbiome associated
metabolic pathways and innate stimulation promote tolerance and barrier function in the OOM. The specific aims
of the Core are to Aim 1) sample and clinically follow up already recruited Cohort 1 infants until 6 years of age
for additional allergic diseases, Aim 2) recruit, sample and clinically follow up a similar cohort 2 of 120 infants
for the development of atopic dermatitis and food allergy until 24mo of age, and Aim 3) prepare, store and share
samples utilized in the Projects 1-3 (cord and infant peripheral blood, stool, skin swabs and tape strips) to assess
farming lifestyle effect on children's gut microbiome, innate and adaptive immune composition, and skin barrier
function and microbiome composition.
These studies aim for novel strategies for primary and secondary prevention of early childhood allergic
diseases.
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