Transcription-based identification of Insulin Resistance Subtypes

基于转录的胰岛素抵抗亚型鉴定

• 批准号: nhmrc : 533824
• 负责人: A/Pr Jeremy Jowett
• 金额: $ 22.8万
• 依托单位: Deakin University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/transcription-based-identification-resistance-subtypes/76238
• 关键词: Transcription; based; identification; Insulin; Resistance

A key feature of type 2 diabetes is the failure of metabolic tissues such as muscle and fat to respond to normal levels of insulin. This 'insulin resistance' is caused by a number of mechanisms. We will use cutting-edge technology to identify small sets of genes that define each variety of insulin resistance. These gene sets will be used to diagnose sub-types of insulin resistance and will facilitate the development of personalised therapies to effectively treat individuals with type 2 diabetes.

2型糖尿病的一个关键特征是代谢组织如肌肉和脂肪对正常水平的胰岛素反应失败。这种“胰岛素抵抗”是由许多机制引起的。我们将使用尖端技术来识别定义每种胰岛素抵抗的小组基因。这些基因集将用于诊断胰岛素抵抗的亚型，并将促进个性化疗法的开发，以有效治疗2型糖尿病患者。