Toward measures and behavioral trials for effective online AUD recovery support

项目摘要/摘要 酒精使用障碍(AUD)是一种常见而严重的健康状况。新冠肺炎疫情进一步恶化 AUD轨迹和获得治疗和同伴支持的更高障碍 改善AUD结果。越来越多的人通过流行的在线方式寻求澳元恢复支持 社交媒体平台上的澳元恢复支持(OARS)论坛。划桨论坛降低社交门槛 对恢复的支持广泛可用，并显示出改善非洲发展成果的希望。然而，由于在那里 没有严格的临床试验侧重于桨论坛的参与，没有足够的证据证明 推荐它们作为支持澳元恢复的有效工具。这样的试验是具有挑战性的，因为 划桨论坛和各种参与方式(例如，使用频率、寻求或给予的支持)。我的 长期的职业目标是成为一名独立的调查员和开发、实施、 以及对有效改善AUD恢复结果的划桨行为方法的评估。 为了填补我在专业知识方面的重大空白，我有四个培训目标：(1)澳元和澳元的概念框架 恢复进程，为这项工作提供坚实的概念基础；(2)重点小组培训 概念图和以人为中心的设计方法，从OARS论坛用户那里收集数据，通知 随后的自我报告量表和干预发展；(3)自然疗法高级方法的培训 语言处理(NLP)文本分类，以推进对划桨行为的严格观察研究 在自然环境中；和(4)行为干预的临床试验设计方面的培训，以开发和 进行试验，评估参与划桨对AUD结果的有效性。我已经组装了一个 AUD和成瘾康复研究人员的多学科指导团队，具有良好的记录 NIAAA的资助和指导。我的顾问在社会恢复过程中提供必要的专业知识， 心理测量学，NLP中的先进方法，以及临床试验开发和统计分析。 拟议的K01研究建立在我之前的工作基础上，重点是划桨、参与和社会的模式 支持。我提出了一个桨行为路径模型(OARS-BPM)来描述 划桨参与和社会支持，这与发展ADD应对技能和 以康复为导向的社会认同。我将开发自我报告量表和相应的NLP文本分类器 确定划桨行为的潜在结构。为了评估和改进OARS-BPM，我将征求焦点小组的反馈 并应用NLP文本分类器来表征公共OARS论坛中的用户行为。基座 根据这些发现，我将进行一项试点随机临床试验，以评估 划桨-基于BPM的干预措施，鼓励3个月以上的结构化划桨参与。因此，我将发展 必要的自我报告和基于NLP的测量工具以及行为临床试验框架，该框架 将加强第一个关于参与划桨疗法改善AUD结果的随机对照试验。

PROJECT SUMMARY/ABSTRACT Alcohol Use Disorder (AUD) is a common and serious health condition. The COVID-19 pandemic worsened AUD trajectories and heightened barriers to accessing treatment and peer support that are effective in improving AUD outcomes. A growing number of people are seeking AUD recovery support via popular Online AUD Recovery Support (OARS) forums on social media platforms. OARS forums lower barriers to social support in recovery, are widely available, and show promise for improving AUD outcomes. However, as there are no rigorous clinical trials focusing on OARS forum participation, there is insufficient evidence to recommend them as effective in supporting AUD recovery. Such trials are challenging, given the variety of OARS forums and the myriad approaches to participation (e.g., frequency of use, support sought or given). My long-term career goal is to become an independent investigator and leader in development, implementation, and assessment of behavioral approaches to OARS that are effective in improving AUD recovery outcomes. To fill crucial gaps in my expertise, I have four training objectives: (1) Conceptual frameworks of AUD and AUD recovery processes, to provide strong conceptual foundations for this work; (2) Training in focus group methods for concept mapping and human-centered design, to collect data from OARS forum users that informs subsequent self-report scale and intervention development; (3) Training in advanced methods for Natural Language Processing (NLP) text classification, to advance rigorous observational research of OARS behaviors in naturalistic settings; and (4) Training in clinical trial design for behavioral interventions, to develop and conduct trials that assess the effectiveness of OARS participation on AUD outcomes. I have assembled a multidisciplinary mentoring team of AUD and addiction recovery researchers with a strong track record of NIAAA funding and mentorship. My consultants provide necessary expertise in social processes of recovery, psychometrics, advanced methods in NLP, and clinical trial development and statistical analysis. The proposed K01 research builds upon my prior work focusing on patterns of OARS participation and social support. I propose an OARS Behavioral Pathway Model (OARS-BPM) to characterize observable behavior of OARS participation and social support, which are associated with development of AUD coping skills and a recovery-oriented social identity. I will develop self-report scales and corresponding NLP text classifiers to identify latent constructs of OARS behavior. To assess and refine OARS-BPM, I will elicit focus group feedback from OARS users and apply NLP text classifiers to characterize user behavior from public OARS forums. Based on these findings, I will conduct a pilot randomized clinical trial to assess feasibility and acceptability of an OARS-BPM based intervention to encourage structured OARS participation over 3 months. Thus, I will develop necessary self-report and NLP-based measurement tools as well as a behavioral clinical trial framework, which will potentiate the first randomized controlled trials of OARS participation on improving AUD outcomes.