Toward measures and behavioral trials for effective online AUD recovery support

采取措施和行为试验以提供有效的在线澳元复苏支持

• 批准号: 10643056
• 负责人: Jason Colditz
• 金额: $ 16.5万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10643056
• 关键词: Adult; Alcohol consumption; Behavior; Behavior Therapy; Behavior assessment; Behavioral; Behavioral trial; COVID-19 pandemic; Classification; Clinical; Clinical Treatment; Clinical Trials; Clinical Trials Design; Code; Collaborations; Computing Methodologies; Conceptual Domain; Coping Skills; Data; Data Reporting; Development; Effectiveness; Emotional; Feedback; Focus Groups; Foundations; Frequencies; Funding; Goals; Health; Health Services Accessibility; Heterogeneity; Human; Intervention; Learning; Measurement; Measures; Mentors; Mentorship; Methods; Modeling; National Institute on Alcohol Abuse and Alcoholism; Natural Language Processing; Observational Study; Outcome; Participant; Pathway interactions; Patient Self-Report; Pattern; Personal Satisfaction; Persons; Procedures; Process; Psychological reinforcement; Psychometrics; Randomized, Controlled Trials; Recommendation; Recovery; Recovery Support; Research; Research Personnel; Social Identification; Social Processes; Social support; Statistical Data Interpretation; Structure; Surveys; Technology; Text; Time; Training; Work; acceptability and feasibility; addiction; alcohol seeking behavior; alcohol use disorder; behavioral clinical trial; behavioral construct; career; concept mapping; cost effective; dashboard; deep learning; effectiveness evaluation; evidence base; evidence based guidelines; experience; feasibility trial; health science research; human centered design; improved; insight; instrument; multidisciplinary; new technology; online intervention; peer; peer support; prospective; randomized, clinical trials; social; social media; social observations; therapy development; tool

PROJECT SUMMARY/ABSTRACT Alcohol Use Disorder (AUD) is a common and serious health condition. The COVID-19 pandemic worsened AUD trajectories and heightened barriers to accessing treatment and peer support that are effective in improving AUD outcomes. A growing number of people are seeking AUD recovery support via popular Online AUD Recovery Support (OARS) forums on social media platforms. OARS forums lower barriers to social support in recovery, are widely available, and show promise for improving AUD outcomes. However, as there are no rigorous clinical trials focusing on OARS forum participation, there is insufficient evidence to recommend them as effective in supporting AUD recovery. Such trials are challenging, given the variety of OARS forums and the myriad approaches to participation (e.g., frequency of use, support sought or given). My long-term career goal is to become an independent investigator and leader in development, implementation, and assessment of behavioral approaches to OARS that are effective in improving AUD recovery outcomes. To fill crucial gaps in my expertise, I have four training objectives: (1) Conceptual frameworks of AUD and AUD recovery processes, to provide strong conceptual foundations for this work; (2) Training in focus group methods for concept mapping and human-centered design, to collect data from OARS forum users that informs subsequent self-report scale and intervention development; (3) Training in advanced methods for Natural Language Processing (NLP) text classification, to advance rigorous observational research of OARS behaviors in naturalistic settings; and (4) Training in clinical trial design for behavioral interventions, to develop and conduct trials that assess the effectiveness of OARS participation on AUD outcomes. I have assembled a multidisciplinary mentoring team of AUD and addiction recovery researchers with a strong track record of NIAAA funding and mentorship. My consultants provide necessary expertise in social processes of recovery, psychometrics, advanced methods in NLP, and clinical trial development and statistical analysis. The proposed K01 research builds upon my prior work focusing on patterns of OARS participation and social support. I propose an OARS Behavioral Pathway Model (OARS-BPM) to characterize observable behavior of OARS participation and social support, which are associated with development of AUD coping skills and a recovery-oriented social identity. I will develop self-report scales and corresponding NLP text classifiers to identify latent constructs of OARS behavior. To assess and refine OARS-BPM, I will elicit focus group feedback from OARS users and apply NLP text classifiers to characterize user behavior from public OARS forums. Based on these findings, I will conduct a pilot randomized clinical trial to assess feasibility and acceptability of an OARS-BPM based intervention to encourage structured OARS participation over 3 months. Thus, I will develop necessary self-report and NLP-based measurement tools as well as a behavioral clinical trial framework, which will potentiate the first randomized controlled trials of OARS participation on improving AUD outcomes.

项目总结/摘要 酒精使用障碍（AUD）是一种常见且严重的健康状况。2019冠状病毒病疫情恶化 AUD轨迹和获得治疗和同伴支持的障碍增加， 改善AUD结果。越来越多的人正在通过流行的在线寻求澳元恢复支持 社交媒体平台上的AUD恢复支持（OARS）论坛。OARS论坛降低了社交障碍 支持复苏，是广泛可用的，并显示出改善澳元结果的承诺。但由于 没有严格的临床试验集中在OARS论坛的参与，没有足够的证据， 建议他们有效地支持澳元复苏。这些试验具有挑战性，因为 OARS论坛和各种参与方式（例如，使用频率、寻求或给予的支持）。我 长期的职业目标是成为一名独立的调查员和开发，实施， 以及评估OARS的行为方法，这些方法可有效改善AUD恢复结果。 为了填补我的专业知识的关键空白，我有四个培训目标：（1）AUD和AUD的概念框架 恢复进程，为这项工作提供坚实的概念基础;（2）重点小组培训 概念图和以人为本的设计方法，从OARS论坛用户那里收集数据， 随后的自我报告量表和干预措施的发展;（3）培训先进的方法，自然 语言处理（NLP）文本分类，以推进对OARS行为的严格观察研究 （4）行为干预的临床试验设计培训， 开展评估OARS参与对AUD结局的有效性的试验。我召集了一个 由AUD和成瘾康复研究人员组成的多学科指导团队，拥有强大的 NIAAA资助和指导。我的顾问提供了社会恢复过程中必要的专业知识， 心理测量学，NLP的先进方法，临床试验开发和统计分析。 拟议的K 01研究建立在我以前的工作重点是OARS参与和社会模式的基础上。 支持.我提出了一个OARS行为路径模型（OARS-BPM）来描述可观察到的行为， OARS参与和社会支持，这与AUD应对技能的发展和 恢复社会认同感。我将开发自我报告量表和相应的NLP文本分类器， 识别OARS行为的潜在结构。为了评估和改进OARS-BPM，我将收集焦点小组的反馈 并应用NLP文本分类器来描述来自公共OARS论坛的用户行为。基于 根据这些发现，我将进行一项试验性随机临床试验，以评估 基于OARS-BPM的干预措施，鼓励结构化的OARS参与超过3个月。因此，我将开发 必要的自我报告和基于NLP的测量工具以及行为临床试验框架， 将加强OARS参与的首个随机对照试验对改善AUD结局的作用。