The transcriptional basis of breast cancer phenotype.

乳腺癌具有多种特征，如对治疗的反应和复发的倾向。我们知道，个体的致癌性病变可能会影响多样性，但产生癌症的细胞类型的特征也可能起作用。本申请解决了这个问题，并研究了申请人的一项重大新发现，即ets转录因子Elf5在指定乳腺癌的多样性中起关键作用。

Breast cancers have diverse characteristics such as their response to treatment and their propensity to relapse. We know that the individual suit of oncogenic lesions probably influences diversity but the characteristics of the cell type from which the cancer arose probably also plays a part. This Application addresses this question and investigates a major new discovery made by the applicant that the ets transcription factor Elf5 plays a key role in specifying the diversity in breast cancer.