Role and mechanism of action of nuclear receptors in steroidogenesis

核受体在类固醇生成中的作用和作用机制

• 批准号: 262224-2008
• 负责人: Tremblay, Jacques
• 金额: $ 1.97万
• 依托单位: Université Laval
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2009
• 资助国家: 加拿大
• 起止时间: 2009-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=426999
• 关键词: Role; mechanism; action; nuclear; receptors

Testicular Leydig cells are the main testosterone-producing cells in the male. These cells are indispensable for the proper development of external male genitalia, sex accessory glands, increased muscle mass, as well as production of mature sperm. Leydig cell function is tightly controlled by the pituitary luteinizing hormone (LH). LH binds to its receptor located on the surface of Leydig cells thus triggering activation of the several intracellular signaling pathways (the main one being the cAMP) leading to increased gene expression and steroidogenesis. The transcription factors downstream of these signaling pathways and their mechanisms of action remain poorly understood. Therefore, the goal of the present research program is to

睾丸间质细胞是雄性动物体内主要的睾酮生成细胞。这些细胞对于男性外生殖器、性附属腺、增加肌肉质量以及产生成熟精子的正常发育是不可或缺的。睾丸间质细胞的功能受到垂体促黄体激素（LH）的严格控制。LH与位于Leydig细胞表面的受体结合，从而触发几种细胞内信号传导途径（主要是cAMP）的激活，导致基因表达和类固醇生成增加。这些信号通路下游的转录因子及其作用机制仍然知之甚少。因此，本研究计划的目标是