Transcriptional Effectors of Oncogenic ERK Signaling in Colorectal Cancer

结直肠癌中致癌 ERK 信号传导的转录效应子

• 批准号: nhmrc : GNT1141906
• 负责人: A/Pr Niall Tebbutt
• 金额: $ 82.08万
• 依托单位: Deakin University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/transcriptional-effectors-oncogenic-colorectal-cancer/1348414
• 关键词: Transcriptional; Effectors; Oncogenic; ERK; Signaling

This project aims to unravel how one of the most frequently deregulated molecular pathways in colorectal cancer controls the expression of genes required for these tumours to grow and spread. We expect this work to uncover novel therapeutic targets to effectively inactivate this pathway and biomarkers to select patients most likely to benefit from existing therapies.

该项目旨在揭示结直肠癌中最常见的失调分子途径之一如何控制这些肿瘤生长和扩散所需的基因表达。我们希望这项工作能够发现新的治疗靶点，以有效地验证这一途径和生物标志物，以选择最有可能从现有疗法中受益的患者。